A peer-reviewed study published in Cell in March 2026 introduces “optovolution,” an in vivo directed-evolution system that uses light to breed proteins capable of switching between active and inactive ...

A research team led by Sahand Jamal Rahi at EPFL’s Laboratory of the Physics of Biological Systems has introduced a new approach called “optovolution.” This technique uses light to guide the evolution ...

Researchers have created a method called optovolution that uses light to guide the evolution of proteins with dynamic behaviors. By engineering yeast cells so their survival depended on proteins ...

Scientists have developed a novel protein evolution approach dubbed optovolution that uses light to guide the evolution of proteins with dynamic, multi-state, and computational functions based on ...

Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

The low efficiency of conventional vectors used for genetic medicines often means delivering them at high doses and by suboptimal routes, leading to inflammation, toxic side effects and limited ...

EPFL researchers have developed a light-based method that can produce proteins that switch states, respond to signals, and even compute, using light and the cell cycle.