Researchers discovered how human cells detect suboptimal codons in mRNA. The protein DHX29 recognizes non-optimal codons and ...

A newly identified cellular system monitors subtle variations in genetic coding, hinting at a hidden level of control over ...

A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...

For decades, scientists working with genetic material have labored with a few basic rules in mind. To start, DNA is transcribed into messenger RNA (mRNA), and mRNA is translated into proteins, which ...

Dengue is the most prevalent mosquito-borne viral disease in the world. Globally, about half of the world’s population is now at risk of dengue with an estimated 100–400 million infections occurring ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...

Two proteins comprising the ZEB family of zinc finger transcription factors, ZEB1 and ZEB2, execute EMT programs in embryonic development and cancer. By studying regulation of their expression, we ...

Conditional survival nomogram after an R0 resection for gastric cancer. Background: Recently, c-kit exon 11 deletions, including codons 557 and/or 558, have been reported to predict a worse prognosis ...

Alternative genetic decoding can be either a global phenomenon that affects the decoding of most or all mRNAs, or a local recoding that affects particular sites in a few mRNAs. Global alterations in ...

A central tenet of biology may need updating given new measurements of start codons. For decades, scientists working with genetic material have labored with a few basic rules in mind. To start, DNA is ...