Twenty-two patients were included (77% female; median age 60 years). Sixty-four percent had sensitizing EGFR mutations, and 32% had an atypical EGFR mutation. Thirteen of the 22 patients (59%) were ...

Immune cells within the cerebrospinal fluid can offer a glimpse of the inflammatory conditions within the brain. According to a study published December 7 in Cell, those immune cells markedly change ...

CHICAGO -- Intracerebroventricular (ICV) delivery of bivalent CAR T-cells targeting EGFR and IL13Rα2 was feasible and appeared safe in patients with recurrent glioblastoma (GBM) in a phase I study ...

In advanced cancers, including breast, lung, and melanoma, leptomeningeal disease (LMD), a condition associated with rapid neurological deterioration, can develop. Treatment options remain limited, ...

Friend or foe? The debate about disease-associated microglia persists eight years after their discovery. If only there was a way to interrogate DAMs in living people and see how they correlate with ...

Influence of Epithelial-Mesenchymal Transition on Risk of Relapse and Outcome to Eribulin or Cyclin-Dependent Kinase Inhibitors in Metastatic Breast Cancer Patients with NSCLC who had CSF collection ...